Study Tests Dose and Toxicity Levels of Treatments For Mesothelioma Victims - Health

A study currently being conducted in Boston, Mass., by several physicians is attempting to determine the highest level of medicinal treatments, such as chemotherapy, that can be administered to mesothelioma victims in order to more adequately treat symptoms of the killer lung disease.

Researchers are using two methods of treatment known as intraoperative intracavitary hyperthermic cisplatin perfusion along with amifostine, to assist in preventing cisplatin toxicity, to patients suffering from malignant pleural mesothelioma, which is often deemed the most severe and fatal diagnosis among mesothelioma patients.

So far the study has found that the use of single dose amifostine does "not protect adequately against cisplatin-induced renal toxicity," meaning that if higher doses of the chemotherapy treatment cisplatin are used, then "additional cytoprotective strategies are needed" to protect a patient from developing toxic levels of medication in addition to their painful mesothelioma side effects.

What is Mesothelioma?

Mesothelioma lung cancer is a fatal condition that can develop after exposure to asbestos fibers and asbestos dust occurs. It is common for individuals who are employed in the field of construction to be at the highest risk for developing mesothelioma cancer, which often remains dormant for years, eating away at a victims interior until it is too late for successful treatment.

Although those working in the construction industry are at an increasing risk of developing mesothelioma cancer, the risk also stems to their family and friends who become exposed to asbestos after an employee covered in asbestos returns home accidentally exposing family and friends to the fiber.

For those who may be concerned about a mesothelioma diagnosis, they can learn more about the condition by contacting a physician and receiving a physical as well as x-rays to ensure that a proper diagnosis as well as treatment is administered. However, it will still be important for a patient to know and recognize the following mesothelioma signs and symptoms as well. Currently, there are two main types of mesothelioma commonly affecting the lining of the lungs and the internal organs: abdominal and lung. The Mayo Clinic reported the following

* symptoms for both conditions:

* shortness of breath

* painful breathing

* painful coughing

* chest pain under the rib cage

* unusual lumps of tissue under the skin on the chest

* unexplained weight loss

* dry cough

* abdominal pain

* abdominal swelling

* change in bowel habits

* lumps of tissue in the abdomen

If an individual develops any of the above side effects, it is imperative that they receive immediate attention from a doctor. Unfortunately, there is a high rate of death linked to a mesothelioma diagnosis, which is commonly due to the fact the disease remains dormant for several years.

Support For Mesothelioma Victims

Mesothelioma sufferers face many challenges as a part of their diagnosis. In order for a victim to receive adequate mesothelioma treatments they must retrieve medical attention, which will assist in easing the pain and symptoms of mesothelioma.

Additionally, it may be necessary to receive details about the development of a mesothelioma lawsuit from an experienced mesothelioma attorney. Constructing a mesothelioma lawsuit will likely assist a victim in receiving monetary compensation, which can pay for the expensive mesothelioma treatments associated with the disease. For the latest on a mesothelioma diagnosis as well as the development of potential litigation, individuals can discuss a mesothelioma lawsuit with a mesothelioma attorney who can provide the most up-to-date news and information on such a case.

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Treatments for Mesothelioma Under Investigation - Law

Researchers continually find ways to treat diseases that seem counter-intuitive to the rest of us. There are hundreds of clinical trials underway at any given time. Clinical trials are research programs that are approved for trial on humans. These trials are restricted to people who meet inclusion and exclusion criteria for that specific study. Clinical trials conducted through four trial phases, each involving a larger number of participants. The fourth phase is a post marketing study.

Several clinical trials are using gene therapy to stimulate immune responses in humans. One treatment in Phase I involves injecting a dose of a gene therapy involving a virus thymidine kinase into the intrapleural space (between the two pleural mesothelial membranes that line the lungs and ribcage) twice daily for 3 days. This treatment showed sufficient promise in the treatment of pleural mesothelioma to recommend it for Phase II testing. Several other gene therapy trials by different groups of researchers use variations of gene therapy with promising results. These trials involved patients with localized pleural mesothelioma.

A double-blind study in Phase II Trial will compare the results of administering the combination of Gemcitabine and Cisplatin with, and without Bevacizumab, a drug that inhibits the growth of blood vessels that can nourish new cancer cells in the hope that the tumor will shrink.

Pemetrexed combined with Cisplatin was compared to Cisplatin alone in a Phase III trial involving patients with metastatic pleural mesothelioma (MPM). The combination of both drugs with the addition of vitamin B12 and folic acid resulted in superior survival time, time to progression, and response rates Adding the vitamins reduced toxicity.

Another study in Phase I involves Pemetrexed and Carboplatin in patients with MPM. During Phase I some of the patients experienced toxicity related to the dosage, however, 70% of the patients experienced improvement in their symptoms after only two courses of treatment. Time to progression was delayed 305 days (about ten months) and median survival time 451 days (about fifteen months.)

Photodynamic therapy is another approach that is currently being studied. Patients are pretreated with light-sensitive molecules that cause the cancer cells to become sensitive to light. During surgery, these cells are exposed to light of a specific wavelength. Though there have been positive results, this treatment also requires more study. In comparison, the patients who qualified for these clinical trials had a life expectancy of six to nine months at the time they entered the trials. While there is still a long way to go, scientists are working to find the key to curing mesothelioma. In the past surgery was done as a palliative treatment.

Fifteen years ago researchers were hopeful that surgery combined with chemotherapy, radiation therapy would provide more significant results than each give separately. Today, therapy combining surgery with chemotherapy, photodynamic therapy and gene therapy are producing encouraging results.

You may be entitled to compensation if you have received a diagnosis of mesothelioma or asbestosis. Please visit the website of Parker, Dumler & Kiely, LLP, the experienced mesothelioma lawyers in Baltimore, Maryland and Washington, D.C.

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Survival Rate after Diagnosis of Mesothelioma - Health - Cancer

Mesothelioma is a new form of cancer induced by asbestos in lungs, heart and abdomen. Anyhow if anybody inhales the particles of asbestos, they stick to the external lining of internal organs and induce cancer there. This is very complicated form of cancer because it reaches to advanced stage until the patient comes to know about his illness. Therefore, it has very less survival rate. Studies on mesothelioma survival rate have shown that only one person survive out of ten after diagnosed with the disease till three years and only one person survive till five years out of twenty after diagnosed with this new form of cancer.

Symptoms of this cancer do not appear till 40 to 45 years after being infected with asbestos and therefore, the average age of the people diagnosed with this disease is 61 years. The major problem with the diagnosis of mesothelioma is that, its symptoms are similar to other respiratory diseases and therefore, it takes long to declare a person suffering with this life threatening disease. This all leads it to less survival rate. This is called life threatening because still no permanent cure could be found for it. There are some treatments but, they just can extend the life of the patient.

Some factors on which survival rate of mesothelioma is based on are- the size of the tumor, stage in which the patient is, the quantity of fluid in the abdomen and chest, duration it took to diagnose the disease, and whether the tumor can surgically be removed completely or not. Still the studies are being performed on this disease and a permanent treatment to increase the survival rate of the patients.

The treatments known to this disease are very expensive but they can be made affordable by asking for compensation money. For that a lawyer, good at pleading for mesothelioma is to be found. Lawyer helps to get more and more amount as compensation money. Therefore, after coming to know about disease not only a doctor but also a lawyer should be contacted to get the amount and compensation you deserve.

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5 commonly used imaging tecniques in the diagnosis of Mesothelioma - Health - Cancer

To make a diagnosis of mesothelioma, doctors usually start with the taking of a detailed medical history from the patient. Once there is enough clinical suspicion from the history the doctor will usually order for certain imaging tests and fluid and tissue sample tests for making a definitive diagnosis. This article will be looking at the different types of imaging tests that are usually used to diagnose mesothelioma.

Some of the most commonly used imaging methods include:

1-Chest X-ray

A chest x-ray can show the following:

-pleural effusion, this is accumulation of excessive fluid in the pleural space either in the right {60%} pleural space or in the left {40%} pleural space. The pleural space is the space between the two layers of the pleural membrane.

-x-ray can also reveal a mass in one of the lungs

-pleural plaques or pleural scarring might be seen.

2-Computed Tomography (CT)

Signs to look out for in the CTscan include:

-pleural thickening and pleural calcification

-thickening of interlobular fissures

-chest wall invasion

CT sans can also be used to guide the needle used in fine needle aspiration of tumor masses used for tissue biopsy.

3- Magnetic Resonance Imaging (MRI) This test produces a multi dimensional image of the tumors and the lung tissue so it is able to clearer picture of the diseased lung. It can show:

-the presence of mediastinal lymph nodes {lymph nodes situated in the tissue that divides the chest cavity into two halves}.

-a clear picture of the diaphragm to show whether it has been affected by the tumor.

4- Positron Emission Tomography (PET)

This is a relatively new technique that is very useful in determining the staging of the tumor.

5-CT/PET

By combining the benefits of CT and PET (anatomic and metabolic information) into a single scan, this technology can more accurately determine the stage of the cancer, and can help identify the best treatment option for the patient.Once mesothelioma is suspected through imaging tests, it is confirmed by pathological examination. Tissue is removed, put under the microscope, and a pathologist makes a definitive diagnosis, and issues a pathology report.Mesothelioma victims should be aware of the different types of diagnostic tests that they might be subjected to so that they can cooperate fully.

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Mesothelioma life expectancy: Important factors that can improve the lifespan of Mesothelioma Patients - Health - Cancer

Good prognostic factors for the survival of mesothelioma are:

1-Early stage at diagnosis.

Patients that are diagnosed when the tumor is still in either stage 1 or stage 2 have a better prognosis than patients that are diagnosed when the tumor is already in the stages 3 and 4 by which stage only symptomatic treatment to reduce the symptoms can only be given.

2- Good general state of health.

The better the state of health the better the patient will be able to withstand the stress of treatment and extensive potentially curative surgery which in turn translates into achieving better results of treatment.

3-Younger age The younger the age of the patient at the time of diagnosis the better the outcome of the treatment for the disease. Older victims tend to have some other chronic age related illnesses like diabetes and hypertension which further decreases the state of health of the patient.

4-Epithelioid subtype

There are different types of mesothelioma based on histological characteristics of the cancer cells{cellular structure of the cells}.The different histological types are the sarcomatoid, the epitheliod type, the biphasic type, and the desmoplastic type. The epitheliod type of cancer however has the best prognosis as it is very responsive to treatment and it does not spread as quickly as the other types.

5- Absence of chest pain. The presence of chest pain could signify that the tumor has infiltrated into the chest wall and other nearby structures thus making treatment difficult.

6- Nil significant weight loss Weight loss is a sign of advanced cancer so if the victim is still of normal weight by the time of diagnosis it means that the tumor is still likely to be localized.

7-Normal levels of a substance in the blood called LDH

8-Normal red blood cell counts, white blood cell counts, and blood platelet counts

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Mesothelioma and Asbestos - Health - Cancer

Asbestos is a fibrous material which has been in use for a long time mainly for its fire resistant qualities. Asbestos is a preferred building material due to its fire resistant and heat resistant capability coupled with the fact that it is not expensive.

Asbestos was very popular amongst California business owners in the early and mid 20's and they used it in nearly every way they could. They tried to use asbestos to create safer, and cheaper buildings, but time has proven that these building are not any safer, nor are they more cheaper,as the high cost of treating the mesothelioma disease that they caused, they also lead to loss of lives.

Asbestos was once used in everything from automotive parts, clothing, and blankets. It was a natural choice for fire fighter gear. The asbestos material, looked like it was the absolute safest and most rewarding discovery of the 20th century, with buildings, homes, and businesses less likely to burn to the ground with the use of asbestos. The fact that about 3000 people died annually from Mesothelioma, made people to start to see things differently after some time.

Mesothelioma is a direct and profound consequence of long term exposure to asbestos. Asbestos fibers are in fact the only known cause of Mesothelioma. The great tragedy of Mesothelioma is far more insidious than the fact that thousands of people are diagnosed with Mesothelioma every year, but that the knowledge of what asbestos may very well do to the interior of those who were around it regularly has been well known since the 1920s.

Mesothelioma is one of the deadliest diseases with a virtual 100% mortality rate.Most cases will die within a year or two. The material that was often used to protect buildings from fire damage affected the internal organs of the people who worked with it, sentencing these hard working Californians early and painful deaths.

Asbestos affects slowly the lining of the organs, usually attacking the lining of the lungs. It may take somewhere between 10 and 40 years before the damage from asbestos becomes evident in the form of Mesothelioma. Those who worked with it never felt ill or had any physical warning signs that there was anything wrong.

The mortality rate has decreased slightly, as those who are now aware that they worked with asbestos in the past are receiving medical evaluations prior to having symptoms. Unfortunately, many of these individuals are finding their vigilance was warranted. However, with early detection, the survival rate has increased slightly.

For so many, early detection was never a possibility. So few companies were willing to inform their employees that they had been exposed to asbestos for fear of being compelled to reach reasonable and fair financial settlements with the victims of Mesothelioma and their families. Companies which had saved so much by effectively placing their employees at considerable risk need qualified California mesothelioma lawyers to stand up to them in order to provide financial relief from the devastation caused by asbestos.

Mesothelioma lawsuits are unfortunately the only available method of holding companies responsible for their asbestos negligence. A valid mesothelioma lawsuit will not only assists the victim in covering his astronomical medical expenses, but they also help to create awareness and ethical actions by other companies faced with choices during construction.

California mesothelioma lawyers who have excelled in the representation of Mesothelioma victims have surpassed most attorneys in providing aggressive care and representation for their clients. Mesothelioma has become such a glaring example of lack of company concern for their valuable employees. Big companies are required to examine their practices and their human obligation because of Mesothelioma lawsuits and the vast expense of Mesothelioma settlements.

Most of the companies chose to provide less than adequate protection for their workers but chose to provide good fire protection for their buildings. They did not mind some of their workers falling ill of even dying as long as they were able to preserve their buildings.

California workers have had enough of California bad business practice of placing production and performance over the health of their workers. The public needs to let these exploitative Carlifornia companies know that they would not allow them to exploit them any longer, they must challenge them in courts through the use of Mesothelioma lawsuits.

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Treatment of epithelioid mesothelioma - Health

Epithelioid mesothelioma is the most common cell type that is relatively uniform in shape and has a tubular pattern with a distinct cell nucleus. Epithelioid is the most common kind; 50-70% cases reported are of this type, which also has the best possibility of survival. This type affects the covering surrounding the internal organs and internal surfaces in the body.

In spite of various new treatment options, the survival rate of Mesothelioma disease is low. These options have helped in increasing the longevity of mesothelioma patients. Statistics indicate that the average survival period after diagnosis is about one year. The survival period might increase up to two years if the proper treatment is done aggressively. More than 95% cases with mesothelioma disease occur due to asbestos exposure.

Epithelium is a tissue separating different regions of the body. Like in the case of epithelial cells found in the skin detaches the outside of the body from the inside of the body. This serves varied responsibilities like protection, absorption, filtration, excretion, secretion or sensory reception.

Causes and symptoms of epithelioid mesothelioma:

There are various causes found of epithelioid mesothelioma. The most common cause of epithelioid mesothelioma is asbestos exposure where the fine particles and which are found thrown in the air either through sawing or cutting. Mainly the membrane lining of chest cavity, lungs, heart or abdominal cavity gets affected in epithelioid mesothelioma.

Usually there are misdiagnoses of the disease as the cells in other forms of cancer look quite similar to epithelioid cells as adenocarcinoma is a type of cancer which is often confused with epithelioid mesothelioma.

Symptoms of epithelioid mesothelioma:

Symptoms can occur after more than 40 to 50 years of being exposed to asbestos. Patients suffering from epithelioid mesothelioma can have a cough, weakness, tiredness along with inability to absorb nutrition causing weight loss. The breathlessness is caused when the tumor does not allow the lungs to expand and when it spreads further it results in severe chest pain.

Diagnosis of epithelioid mesothelioma

A methodical diagnosis is needed prior to any kind of treatment for mesothelioma. As the latency period of this disease's appearance of the symptoms early diagnosis becomes a difficult proposition. It is usually done only at the advanced stage leading to a survival rate of about 8 to 9 months.

Get more information about epithelioid mesothelioma and its treatment options at New Mesothelioma Treatments. The website provides reliable information about epithelioid mesothelioma for the mesothelioma patients throughout the World.

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